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Richard Henry Parrish II's avatar

Yes, laughing gas (nitrous oxide) is a legal substance, not a controlled substance, in the US. However, unlike oxygen, nitrous oxide distributors are legally required to deliver N2O tanks to licensed healthcare facilities. There is another requirement for mask use, such as specific labor and delivery units, home-hospice palliative care protocols, or mobile emergency medical services (EMS) where pre-mixed 50/50 N2O and oxygen systems (commonly known by brand names like Entonox) may be ordered. These are the current restrictions for personal use that I know of.

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